Telomerasas: funciones en el ciclo celular y perspectivas de aplicación en el tratamiento del cáncer

Yasmany Fornaris Cedeño; Lidia Cecilia Pérez Acevedo; Pedro Manuel García Verdecia; Lázaro Eduardo Valdés Izaguirre

Telomerasas: funciones en el ciclo celular y perspectivas de aplicación en el tratamiento del cáncer

Yasmany Fornaris Cedeño, Lidia Cecilia Pérez Acevedo, Pedro Manuel García Verdecia, Lázaro Eduardo Valdés Izaguirre

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Resumen

Recientemente, se ha estudiado el comportamiento de las enzimas en células cancerosas y sus posibles aplicaciones diagnósticas y terapéuticas. En busca de la caracterización de la estructura, el mecanismo de acción y la regulación de una de ellas, la telomerasa, así como sus potencialidades en el tratamiento de las enfermedades proliferativas, se desarrolla esta consulta bibliográfica de 41 artículos científicos sobre el tema. En ella se reafirma el llamado a la comunidad científica mundial a que retome este importante campo de investigación, debido a la corroboración de que las telomerasas participan en la inmortalidad de las células cancerosas, por lo que pueden constituir una alternativa viable en el desarrollo de terapéuticas orientadas al tratamiento de patologías celulares ploriferativas

ABSTRACT

Recently, the behavior of these enzymes has been studied in cancerous cells and its diagnostic and therapeutic possible applications. With the objective of characterizing the structure, the action mechanism and the regulation of the telomerases as well as their potentialities in the treatment of the proliferative illnesses, a bibliographical consultation of 41 scientific articles was developed. telomerases participate in the immortality of the cancerous cells and they constitute an alternative in the development of therapies guided toward the treatment of proliferative cellular pathologies, what justifies the necessity to make a call to the scientific world community so that it recaptures this important investigation field

Palabras clave

telómero; telomerasa; ciclo celular; telomere; telomerase; cellular cycle

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