Hipotermia como alternativa terapéutica

Gabriel Guillen Garcia del Barco; Héctor Pérez-Saad

Hipotermia como alternativa terapéutica

Gabriel Guillen Garcia del Barco, Héctor Pérez-Saad

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Resumen

La hipotermia terapéuticaconsiste en mantener una temperatura corporal específica por un período determinado y está dirigida a reducir las secuelas de laisquemiaen el sistema nervioso. En este trabajo se exponen los mecanismos del daño celular inducido por la isquemia y se describenlos procesos bioquímicos en los que incide el efecto de la hipotermia. Se revisaron 43 artículos indexados en PubMed. Los objetivos de este trabajo se dirigen adescribir los efectos beneficiosos de la hipotermia terapéutica en el contexto de la respiración celular afectada por el evento isquémico, y a describir, desde un punto de vista molecular, el efecto neuroprotector de la hipotermia. La comprensión de los elementos asociados al beneficio de la hipotermia terapéutica permite integrar conocimientos de las ciencias básicas con situaciones clínicas y contribuye a incentivar el aprendizaje significativo en estudiantes de medicina.

Palabras clave

Hipotermia terapéutica, isquemia cerebral, excitotoxicidad apoptosis, inflamación.

Referencias

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